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In addition to the PXR, several other nuclear receptors exist including the retinoid X receptor (RXR), the farnesoid X receptor (FXR), and the constitutive androstane receptor (CAR) which all have similar inductive effects on other CYP450 enzymes.15 So what does this all mean for individuals taking or tapering off of psychiatric medications

Elderly, Cachectic, or Debilitated Patients Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics, including clearance, compared to younger, healthier patients [see WARNINGS

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